NASAL SNIFFING BEATS TAKING ORAL MEDS

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NASAL SNIFFING BEATS TAKING ORAL MEDS

From painkillers to cancer therapies, the latest research shows that medication can be most effective when taken nasally.

We are losing all our effective antibiotics and we need something else. Many substances that are applied in the nose of patients in vitro work against viruses but failed to work in clinical trials in patients.

A nasal spray to shore up your own natural defense systems may be the answer to beating the cold. A white blood cell compound attacks bacteria viruses and fungi and kills them by creating a chlorine cover around microorganisms. There is no danger of growing resistance since it is based on our immune system (A spray containing an analog of CHLOROTAURINE).

ANTI-FLU SPRAYS

How can we protect the people from getting infected by the flu? Anti-flu drugs are used to treat the infection but fail to kill or resist a virus.

Usually the virus enters the nose throat and lungs by locking onto a sugar sticking out from their surface. Proteins bind to the sugar and stop the flu bug in its tracks. The virus keeps expanding until cells are killed. Targeting the sugar rather than a virus helps the drug work on bugs. The spray is given like an asthma inhaler.
Most drugs, used for the treatment of influenza, cannot work on a virus because it becomes resistant to the drugs.

These nasal sprays may stimulate your own defense system. Intranasal delivery of drugs is under investigation for more than two dozen conditions.

Nasal gels and fluids are used to prevent bacterial and viral infections as varied as MRSA, Flu, Sars, Ebola, cancer alleviation of cancer symptoms, and many new forms of vaccines.

ADVANTAGES OF NASAL DOSING

In order to ensure the therapeutic amount gets to the right place, larger doses of drugs must be given orally and the risk of side effects increases.

Research on antihistamines and hay fever shows that while an oral dose can lead to drowsiness, no such side effect occurs when it is given intranasally. Since the required dose is much smaller, stomach upsets associated with some oral drugs are also less likely.

Another big advantage of nasal sniffing is, that it is a direct route into the circulation. The noses inner surfaces, all 150 square centimeters, are rich in tiny veins that help the drugs get into the circulation directly.
Once in the circulation, the drug has a direct and rapid way to work more quickly.

Nasal sprays can deliver molecules called neuropeptides directly to the brain. These molecules include insulin and other hormones--- that communicate with the brain. Nasal sprays quickly cross the blood-barrier and prevent the accumulation of the drug. Nasal delivery is also useful in treating brain diseases, such as Alzheimer's disease and obesity.

DIABETES

Diabetic patients soon will be able to use a small inhaler containing a cartridge of insulin powder, which is inhaled into the lungs, dissolve there, and then travels through the bloodstream.

The insulin doses will be prepackaged in cartridges. A mouthpiece is used to release the insulin. No electricity or compress gas will be used. The patient's own breathing will do the job. The airflow through the cartridge allows the powder to be inhaled. This small sized inhaler, called dreamboat, soon may enter the market with FDA approval.

WEIGHT LOSS

Insulin plays a pivotal role in regulation of central nervous system functions, as memory processing and energy metabolism, for weight loss.

ALZHEIMER’S

Since part of the malfunction of the nervous systems signaling is involved, nasal spray insulin may help in the treatment of cognitive and metabolic disorders, such as obesity and Alzheimer's.

Gender seems to be a critical factor in brain insulin signaling affecting both food intake and cognitive functions. Insulin given intranasally, decreases food intake in men but surprisingly not in women. The compound improves memory function in women but not in men.

IMPROVING MEMORY

A molecule from the body's immune system (interleukin-6) when administered through the nose helps the brain retain emotional and procedural memories during REM sleep. A nasal spray can improve memory,

Interleukin-6 ,plays a beneficial role in sleep-dependent formation of long-term memory in humans. (University of Lubeck, Germany).

COLD DISORDERS

We are losing all of our effective antibiotics, and we simply need something else. A nasal spray that mimics our own natural defense system may be the answer to beating the common cold, It works like bleach, creating a chlorine cover around bacteria, viruses and fungi, which kills them. The spray has already proved effective against MRSA.

FLU PREVENTIONS

A nasal spray can protect you from getting infected by the flu bug (researchers at St Andrews University).

Usually, a flu virus enters the cells through nose, throat and lungs by locking on to a sugar that is sticking out from the cell’s surface. Once inside the human body, the virus keeps on expanding itself, killing the cells.

Instead of attacking the flu bug directly, ranges of proteins are used to bind the sugar and stop the flu bug in its tracks. Targeting the sugar rather than the virus itself helps the drug to work on bug. The spray is given like an asthma inhaler and gets quickly into the respiratory track.

PAIN RELIEF

Acute pain is a key target for new nasal drugs, largely because of the speed of their action. Morphine is being used to combat cancer pain, while other drugs are nasal sprays tackle cluster headache, post-operative pain, and dental pain.

AUTISM

Autism is a developmental disorder with symptoms that include poor social functioning and repetitive behaviors. Low levels of oxytocin, a brain chemical involved in emotion, may be involved in the development of autism.
A daily nasal spray, based on the hormone oxytocin, has been used to treat autism symptoms in adults. (Mount Sinai School of Medicine, New York). Other studies found that oxytocin plays a role in social bonding, memory, anxiety reduction, and repetitive behaviors.

MEMORY AND FORGETFULNESS

Insulin plays a role in normal memory processes. Insulin abnormalities may contribute to brain changes associated with Alzheimer's.

Nasal insulin can boost memory in both healthy older people and those with Alzheimer's. Both the healthy and the Alzheimer's patients performed significantly better on memory tests after getting insulin than getting a placebo

FEMALE VIAGRA

Nasal delivery may boost libido in women. A nose spray based on testosterone, currently in development, increases libido in women over 40, and improves sexual arousal. Women who had the nasal testosterone, when shown sexual test pictures had a greater emotional response.

OTHER NASAL USES

Health regulators approved a generic nasal spray to treat osteoporosis, making bones stronger. This calcitonin nasal spray is the copycat version of Micalcin, which is marketed by Novartis. The nasal spray is indicated in females who have low bone mass, after five years or more of menopause.

PROSTATE

Buserelin, a class of medicines (called LHRH analogues works by decreasing the production of sex hormones. Suprefact, a nasal spray, is used to treat cancer of the prostate by reducing levels of testosterone.

COMMENTARY

From painkillers to cancer therapies, the latest research shows that medication can be most effective when taken nasally. Nasal sprays can stimulate your own immune system, and prevent bacterial and viral infections.

This method of delivery is now being used for delivering vaccines, cancer symptoms, Alzheimer's disease, obesity, prostate cancer, memory loss, and loss of female libido.

The required doses are much less and side effects are few. It offers a direct route into the circulation. Insulin and other hormones can be directly delivered to the brain, crossing the blood brain barrier and drug accumulation can be prevented.

It has been found useful in the treatment of Alzheimer’s disease obesity. Interleukin-6, administered nasally, helps the brain retain emotional and procedural memories during sleep.

Having lost all our effective antibiotics, the drug companies are turning to nasal sprays for the treatment of many diseases.

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